Researchers cited MBF Bioscience systems in 10 papers between 4/13/2018 and 4/20/2018

Stereo Investigator:

Cordaro, M., Siracusa, R., Crupi, R., Impellizzeri, D., Peritore, A. F., D’Amico, R., . . . Cuzzocrea, S. (2018). 2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease. Molecular Neurobiology. doi: 10.1007/s12035-018-1064-2.

Heilbronner, S. R., Meyer, M. A. A., Choi, E. Y., & Haber, S. N. (2018). How do cortico-striatal projections impact on downstream pallidal circuitry?  Brain Structure and Function. doi: 10.1007/s00429-018-1662-9.

Miguel-Hidalgo, J., Moulana, M., Deloach, P., & Rajkowska, G. (2018). F103. Reduced Extent of Myelin Basic Protein Immunoreactivity in Rat Prelimbic and Orbitofrontal Cortices After Chronic Unpredictable Stress and its Correlation With Connexin 43 and Connexin 30. Biological Psychiatry, 83(9), S277-S278. doi: 10.1016/j.biopsych.2018.02.716.

Misheneva, V., McFarland, R., Jouroukhin, Y., Severance, E., Yolken, R., & Pletnikov, M. (2018). F101. Animal Models of Mood Disorders and the Evaluation of Probiotics. Biological Psychiatry, 83(9), S276-S277. doi: 10.1016/j.biopsych.2018.02.714.

Walters, K. A., Edwards, M. C., Tesic, D., Caldwell, A. S., Jimenez, M., Smith, J. T., & Handelsman, D. J. (2018). The Role of Central Androgen Receptor Actions in Regulating the Hypothalamic-Pituitary-Ovarian Axis. Neuroendocrinology. doi: Continue reading “Researchers cited MBF Bioscience systems in 10 papers between 4/13/2018 and 4/20/2018” »

Researchers cited MBF Bioscience systems in 16 papers between 4/6/2018 and 4/13/2018

Stereo Investigator: 

Chen, C., Li, X., Ge, G., Liu, J., Biju, K. C., Laing, S. D., . . . Li, S. (2018). GDNF-expressing macrophages mitigate loss of dopamine neurons and improve Parkinsonian symptoms in MitoPark mice. Scientific Reports, 8(1), 5460. doi: 10.1038/s41598-018-23795-4.

Demars, F., Clark, K., Wyeth, M. S., Abrams, E., & Buckmaster, P. S. (2018). A single subconvulsant dose of domoic acid at mid-gestation does not cause temporal lobe epilepsy in mice. Neurotoxicology. doi:

Garrett, L., Ung, M. C., Heermann, T., Niedermeier, K. M., & Hölter, S. (2018). Analysis of Neuropsychiatric Disease‐Related Functional Neuroanatomical Markers in Mice. Current Protocols in Mouse Biology, 8(1), 79-128. doi:10.1002/cpmo.37.

Piontkewitz, Y., Arad, M., & Weiner, I. (2018). T194. BRAIN STRUCTURAL AND BEHAVIORAL ABNORMALITIES FOLLOWING PRENATAL EXPOSURE TO MATERNAL INFLAMMATION ARE PREVENTED BY EARLY BUT NOT LATE INTERVENTION. Schizophrenia Bulletin, 44(suppl_1), S191-S192. doi: 10.1093/schbul/sby016.470.  Continue reading “Researchers cited MBF Bioscience systems in 16 papers between 4/6/2018 and 4/13/2018” »

Researchers cited MBF Bioscience systems in 27 papers between 3/23/2018 and 4/6/2018

Stereo Investigator: 
Crupi, R., Impellizzeri, D., Cordaro, M., Siracusa, R., Casili, G., Evangelista, M., & Cuzzocrea, S. (2018). N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged Mice.  Molecular Neurobiology. doi: 10.1007/s12035-018-0959-2.

Dingle, A. M., Yap, K. K., Gerrand, Y.-W., Taylor, C. J., Keramidaris, E., Lokmic, Z., . . . Mitchell, G. M. (2018). Characterization of isolated liver sinusoidal endothelial cells for liver bioengineering. Angiogenesis. doi: 10.1007/s10456-018-9610-0.

Duthie, M. S., Pena, M. T., Ebenezer, G. J., Gillis, T. P., Sharma, R., Cunningham, K., . . . Reed, S. G. (2018). LepVax, a defined subunit vaccine that provides effective pre-exposure and post-exposure prophylaxis of M. leprae infection. npj Vaccines, 3(1), 12. doi: 10.1038/s41541-018-0050-z.

Dutta, R. R., Taffe, M. A., & Mandyam, C. D. (2018). Chronic administration of amphetamines disturbs development of neural progenitor cells in young adult nonhuman primates. Progress in Neuro-Psychopharmacology and Biological Psychiatry. doi:

Hormigo, S., López, D. E., Cardoso, A., Zapata, G., Sepúlveda, J., & Castellano, O. (2018). Direct and indirect nigrofugal projections to the nucleus reticularis pontis caudalis mediate in the motor execution of the acoustic startle reflex. Brain Structure and Function. doi: 10.1007/s00429-018-1654-9.

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Researchers cited MBF Bioscience systems in 13 papers between 3/16/2018 and 3/23/2018

Stereo Investigator:
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Cisbani, G., Le Behot, A., Plante, M.-M., Préfontaine, P., Lecordier, M., & Rivest, S. (2018). Role of the chemokine receptors CCR2 and CX3CR1 in an experimental model of thrombotic stroke. Brain, Behavior, and Immunity. doi:

Du, R.-H., Sun, H.-B., Hu, Z.-L., Lu, M., Ding, J.-H., & Hu, G. (2018). Kir6.1/K-ATP channel modulates microglia phenotypes: implication in Parkinson’s disease. Cell death & disease, 9(3), 404. doi: 10.1038/s41419-018-0437-9.

McGowan, S. E., & McCoy, D. M. (2018). Neuropilin-1and platelet-derived growth factor receptors cooperatively regulate intermediate filaments and mesenchymal cell migration during alveolar septation. American Journal of Physiology-Lung Cellular and Molecular Physiology.

Nagahara, A. H., Wilson, B. R., Ivasyk, I., Kovacs, I., Rawalji, S., Bringas, J. R., . . . Bankiewicz, K. S. (2018). MR-guided delivery of AAV2-BDNF into the entorhinal cortex of non-human primates. Gene Therapy, 1.


Brudvig, J. J., Cain, J. T., Schmidt-Grimminger, G. G., Stumpo, D. J., Roux, K. J., Blackshear, P. J., & Weimer, J. M. (2018). MARCKS Is Necessary for Netrin-DCC Signaling and Corpus Callosum Formation.  Molecular Neurobiology. doi: 10.1007/s12035-018-0990-3.

Carr, H., Alexander, T. C., Groves, T., Kiffer, F., Wang, J., Price, E., . . . Allen, A. R. (2018). Early effects of 16O radiation on Neuronal Morphology and Cognition in a Murine Model. Life Sciences in Space Research. doi: reading “Researchers cited MBF Bioscience systems in 13 papers between 3/16/2018 and 3/23/2018” »

Researchers cited MBF Bioscience systems in 11 papers between 3/9/2018 and 3/16/2018

Stereo Investigator:
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Deroche-Gamonet, V., Revest, J.-M., Fiancette, J.-F., Balado, E., Koehl, M., Grosjean, N., . . . Piazza, P.-V. (2018). Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior. Molecular Psychiatry. doi: 10.1038/s41380-018-0038-0.

Mendez-Gomez, H. R., Singh, J., Meyers, C., Chen, W., Gorbatyuk, O. S., & Muzyczka, N. (2018). The Lipase Activity of Phospholipase D2 is Responsible for Nigral Neurodegeneration in a Rat Model of Parkinson’s Disease. Neuroscience. doi:

Wang, Y., Wang, Y., Liu, J., & Wang, X. (2018). Electroacupuncture Alleviates Motor Symptoms and Up-Regulates Vesicular Glutamatergic Transporter 1 Expression in the Subthalamic Nucleus in a Unilateral 6-Hydroxydopamine-Lesioned Hemi-Parkinsonian Rat Model.  Neuroscience bulletin. doi: 10.1007/s12264-018-0213-y.


Borreca, A., Latina, V., Corsetti, V., Middei, S., Piccinin, S., Della Valle, F., . . . Amadoro, G. (2018). AD-Related N-Terminal Truncated Tau Is Sufficient to Recapitulate In Vivo the Early Perturbations of Human Neuropathology: Implications for Immunotherapy. Molecular Neurobiology. doi: 10.1007/s12035-018-0974-3.

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Researchers cited MBF Bioscience systems in 28 papers between 3/2/2018 and 3/9/2018

Stereo Investigator:
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Akca, G., Eren, H., Tumkaya, L., Mercantepe, T., Horsanali, M. O., Deveci, E., . . . Yilmaz, A. (2018). The protective effect of astaxanthin against cisplatin-induced nephrotoxicity in rats. Biomedicine and Pharmacotherapy, 100, 575-582. doi:

Aytan, N., Choi, J.-K., Carreras, I., Crabtree, L., Nguyen, B., Lehar, M., . . . Dedeoglu, A. Protective effects of 7,8-dihydroxyflavone on neuropathological and neurochemical changes in a mouse model of Alzheimer’s disease. European Journal of Pharmacology. doi:

Chu, X., Zhou, S., Sun, R., Wang, L., Xing, C., Liang, R., & Kong, Q. (2018). Chrysophanol Relieves Cognition Deficits and Neuronal Loss Through Inhibition of Inflammation in Diabetic Mice. Neurochemical Research. doi: 10.1007/s11064-018-2503-1.

Domínguez-Álvaro, M., Montero-Crespo, M., Blazquez-Llorca, L., Insausti, R., DeFelipe, J., & Alonso-Nanclares, L. (2018). Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer’s disease patients. Acta Neuropathologica Communications, 6(1), 20. doi: 10.1186/s40478-018-0520-6.

El Massri, N., Weinrich, T. W., Kam, J. H., Jeffery, G., & Mitrofanis, J. (2018). Photobiomodulation reduces gliosis in the basal ganglia of aged mice. Neurobiology of Aging. doi:

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Researchers cited MBF Bioscience systems in 15 papers between 12/8/2017 and 12/15/2017

Stereo Investigator:
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Garcia-Miralles, M., Geva, M., Tan, J. Y., Yusof, N. A. B. M., Cha, Y., Kusko, R., . . . Pouladi, M. A. (2017). Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice. JCI Insight, 2(23). doi: 10.1172/jci.insight.95665.

Gomez-Smith, M., Janik, R., Lake, E. M., Thomason, L. A. M., Adams, C., Jeffers, M. S., . . . Corbett, D. (2017). Reduced Cerebrovascular Reactivity and Increased Resting Cerebral Perfusion in Rats Exposed to a Cafeteria Diet. Neuroscience. doi:

Hawkins, R. F. W., Patenaude, A., Dumas, A., Jain, R., Tesfagiorgis, Y., Kerfoot, S., . . . Vallières, L. (2017). ICAM1+ neutrophils promote chronic inflammation via ASPRV1 in B cell–dependent autoimmune encephalomyelitis. JCI Insight, 2(23). doi: 10.1172/jci.insight.96882.

Joseph, M., Anglada-Huguet, M., Paesler, K., Mandelkow, E., & Mandelkow, E.-M. (2017). Anti-aggregant tau mutant promotes neurogenesis. Molecular Neurodegeneration, 12(1), 88. doi: 10.1186/s13024-017-0230-8.

Kelm-Nelson, C. A., Brauer, A. F. L., Barth, K. J., Lake, J. M., Sinnen, M. L. K., Stehula, F. J., . . . Ciucci, M. R. (2018). Characterization of early-onset motor deficits in the Pink1−/− mouse model of Parkinson disease. Brain Research, 1680, 1-12. doi:

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NeuroMorpho.Org Releases Nearly 10,000 New Neuron Reconstructions and Neurolucida leads the way

Image Courtesy: Bob Jacobs, Ph.D. , Colorado College

With the release of its new version on November 28, adds 9,987 new images to its archive, bringing its impressive collection of digitally reconstructed neurons to 80,012.

Scientists used MBF Bioscience’s software, Neurolucida and Neurolucida 360, to reconstruct the majority of these cells. In fact, 64 times more neurons were reconstructed with MBF Bioscience software than those imaged by our closest commercial competitor – that’s 42,121 reconstructions compared to 656. This metric demonstrates that Neurolucida and Neurolucida 360 are truly the gold standards for neuron reconstruction.

Featuring contributions from hundreds of laboratories from around the globe, NeuroMorpho.Org is the world’s leading database of publicly accessible 3D neuronal reconstructions and associated metadata. From the dragonfly to the humpback whale, researchers have access to accurate and verified data from an array of different organisms. Arranged by animal species, brain region, cell type, or contributing laboratory, each file contains specific details about the cell’s morphology such as age, developmental stage, soma volume, and number of branches – all of which are searchable.

Recently, NeuroMorpho.Org hit the 8 million download mark, with researchers in 166 different countries accessing this valuable resource, and more than one thousand published articles referencing its data

MBF Bioscience unveils whole mouse brain automatic region delineation and cell mapping with the Allen Mouse Brain Reference Atlas

An experimental coronal mouse brain section automatically aligned to the Allen Mouse Brain Reference Atlas

Analyzing cellular populations within specific anatomies in brain images requires expertise in both neuroanatomy and cellular identification. This typically involves a scientist comparing experimental images with a reference atlas and manually delineating anatomical regions and marking cell populations within. NeuroInfo®, a revolutionary new technology from MBF Bioscience, enables researchers to automatically identify and delineate mouse brain regions based on the publicly available Allen Mouse Brain Reference Atlas.

“NeuroInfo has the potential to greatly improve our understanding of how mental disorders influence neuronal cell populations,” says Nathan O’Connor Ph.D., product manager at MBF Bioscience. “Because it makes identifying brain regions substantially faster and more accurate, researchers will be able to explore many more brain regions.”

“The Allen Mouse Brain Reference Atlas is a valuable tool to assist scientists in their research. We’re thrilled that MBF has chosen to integrate this resource into NeuroInfo,” stated Amy Bernard, Ph.D., Product Architect at the Allen Institute for Brain Science.

“Using this remarkable technology, neuroscientists will obtain more repeatable, objective analyses that have been possible to date. Thanks to the integration with the Allen Mouse Brain Reference Atlas, these analyses will be more standardized so that they can be compared across experiments and laboratories,” says Jack Glaser, President.

NeuroInfo can be used with MBF Bioscience’s slide scanning software and virtually all commercial whole slide scanners. The data from NeuroInfo seamlessly integrates with MBF Bioscience’s products including Neurolucida, Stereo Investigator, Biolucida, and BrainMaker.

The tools in NeuroInfo allow researchers to automatically delineate anatomies in the experimental specimens, and detect cells within these anatomies. NeuroInfo yields data that can be invaluable to better understand the organization and composition of the nervous system, and to further knowledge in neurogenomics, transcriptomics, proteomics, and connectomics.

The National Institute of Mental Health provides funding to support the development of NeuroInfo.

Researchers cited MBF Bioscience systems in 30 papers between 09/01/2017 and 09/22/2017

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Bebber, M. R. (2017). Tempered strength: A controlled experiment assessing opportunity costs of adding temper to clay. Journal of Archaeological Science, 86, 1-13. doi:

de Ávila, C., Chometton, S., Lenglos, C., Calvez, J., Gundlach, A. L., & Timofeeva, E. (2017). Differential effects of relaxin-3 and a selective relaxin-3 receptor agonist on food and water intake and hypothalamic neuronal activity in rats. Behavioural Brain Research. doi:

El-Feky, G. S., El-Banna, S. T., El-Bahy, G. S., Abdelrazek, E. M., & Kamal, M. (2017). Alginate coated chitosan nanogel for the controlled topical delivery of Silver sulfadiazine. Carbohydrate Polymers. doi:

Chikama, K., Yamada, H., Tsukamoto, T., Kajitani, K., Nakabeppu, Y., & Uchimura, N. (2017). Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse. Brain Research, 1676(Supplement C), 77-82. doi:

Ghuman, H., Gerwig, M., Nicholls, F. J., Liu, J. R., Donnelly, J., Badylak, S. F., & Modo, M. (2017). Long-term retention of ECM hydrogel after implantation into a sub-acute stroke cavity reduces lesion volume. Acta Biomaterialia. doi:

Hawlitschka, A., Holzmann, C., Witt, S., Spiewok, J., Neumann, A.-M., Schmitt, O., . . . Antipova, V. (2017). Intrastriatally injected botulinum neurotoxin-A differently effects cholinergic and dopaminergic fibers in C57BL/6 mice. Brain Research, 1676(Supplement C), 46-56. doi:

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