American Association of Anatomists Launches Virtual Microscopy Database powered by Biolucida

Free resource for educators and researchers features thousands of downloadable histology slides

Educators and researchers around the world now have free access to a database of whole slide images (also known as virtual slides) for histology and pathology. Featuring thousands of virtual slides contributed by 15 universities, The Virtual Microscopy Database, VMD, (http://www.virtualmicroscopydatabase.org/) is an online resource that allows educators to view and download virtual images and share their own.

Powered by MBF Bioscience‘s Biolucida® for Medical Education solution, VMD gives educators an overview of individual slides and allows examination of various parts of the image at magnifications up to 40x. The users can take a screenshot or download the file at any time.

Funded by an Innovations Program Grant awarded by the American Association of Anatomists (AAA), the resource was developed by researchers from the University of Colorado, Drexel University College of Medicine, and the University of Michigan with corporate support from MBF Bioscience. With thousands of freely accessible virtual microscopy images, the VMD helps meet a growing need for better access to histology slides among educators and non-profit research organizations. The AAA foresees the images being used in a variety of educational ways such as for lectures, exams, and for creating supplementary course material as well as for non-profit research initiatives.

Collection of Virtual Slides in the Biolucida Viewer

“The greatest strength of the VMD is the availability of a large number of high quality virtual microscopy images to its users. The diversity and multiple examples of histological variations available in the VMD collections will enable histology and pathology educators to elevate the quality of their teaching by exposing their students to a broader variety of images and by experimenting with new pedagogical techniques in their classrooms.” (Lisa Lee, Ph.D., University of Colorado)

“We are proud to be part of the AAA’s efforts to improve the access of histology and pathology digital slides for medical educators and students by providing the underlying technology for this important resource. Any of the virtual slides in this new resource can be downloaded and used on an organization’s Biolucida on-premise or cloud-based server,” says Jack Glaser, president of MBF Bioscience.

Individuals affiliated with educational or research institutions may register to access the database. Once approved, users can browse files, or search for specific types of tissue. Currently, the VMD site includes over 2,600 virtual microscopy files, but as new users join the VMD file sharing community that number will grow as will the diversity of tissue and species type.

About AAA:

The American Association of Anatomists was founded by Joseph Leidy in Washington, D.C. in 1888 for the “advancement of anatomical science.” Today, via research, education, and professional development activities, AAA serves as the professional home for an international community of biomedical researchers and educators focusing on the structural foundation of health and disease.

About MBF Bioscience:

MBF Bioscience produces advanced microscopy imaging and analysis systems for biomedical research and education. The award-winning company was co-founded in 1988 by Edmund and Jack Glaser.

www.mbfbioscience.com

Contact:

Nathan O’Connor, Ph.D.

Product Manager/Technical Sales

nate.oconnor@mbfbioscience.com

1-802-288-9290

Researchers cited MBF Bioscience systems in 15 papers between 12/8/2017 and 12/15/2017

Stereo Investigator:
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Garcia-Miralles, M., Geva, M., Tan, J. Y., Yusof, N. A. B. M., Cha, Y., Kusko, R., . . . Pouladi, M. A. (2017). Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice. JCI Insight, 2(23). doi: 10.1172/jci.insight.95665.

Gomez-Smith, M., Janik, R., Lake, E. M., Thomason, L. A. M., Adams, C., Jeffers, M. S., . . . Corbett, D. (2017). Reduced Cerebrovascular Reactivity and Increased Resting Cerebral Perfusion in Rats Exposed to a Cafeteria Diet. Neuroscience. doi: https://doi.org/10.1016/j.neuroscience.2017.11.054.

Hawkins, R. F. W., Patenaude, A., Dumas, A., Jain, R., Tesfagiorgis, Y., Kerfoot, S., . . . Vallières, L. (2017). ICAM1+ neutrophils promote chronic inflammation via ASPRV1 in B cell–dependent autoimmune encephalomyelitis. JCI Insight, 2(23). doi: 10.1172/jci.insight.96882.

Joseph, M., Anglada-Huguet, M., Paesler, K., Mandelkow, E., & Mandelkow, E.-M. (2017). Anti-aggregant tau mutant promotes neurogenesis. Molecular Neurodegeneration, 12(1), 88. doi: 10.1186/s13024-017-0230-8.

Kelm-Nelson, C. A., Brauer, A. F. L., Barth, K. J., Lake, J. M., Sinnen, M. L. K., Stehula, F. J., . . . Ciucci, M. R. (2018). Characterization of early-onset motor deficits in the Pink1−/− mouse model of Parkinson disease. Brain Research, 1680, 1-12. doi: https://doi.org/10.1016/j.brainres.2017.12.002.

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NeuroMorpho.Org Releases Nearly 10,000 New Neuron Reconstructions and Neurolucida leads the way

Image Courtesy: Bob Jacobs, Ph.D. , Colorado College

With the release of its new version on November 28, NeuroMorpho.org adds 9,987 new images to its archive, bringing its impressive collection of digitally reconstructed neurons to 80,012.

Scientists used MBF Bioscience’s software, Neurolucida and Neurolucida 360, to reconstruct the majority of these cells. In fact, 64 times more neurons were reconstructed with MBF Bioscience software than those imaged by our closest commercial competitor – that’s 42,121 reconstructions compared to 656. This metric demonstrates that Neurolucida and Neurolucida 360 are truly the gold standards for neuron reconstruction.

Featuring contributions from hundreds of laboratories from around the globe, NeuroMorpho.Org is the world’s leading database of publicly accessible 3D neuronal reconstructions and associated metadata. From the dragonfly to the humpback whale, researchers have access to accurate and verified data from an array of different organisms. Arranged by animal species, brain region, cell type, or contributing laboratory, each file contains specific details about the cell’s morphology such as age, developmental stage, soma volume, and number of branches – all of which are searchable.

Recently, NeuroMorpho.Org hit the 8 million download mark, with researchers in 166 different countries accessing this valuable resource, and more than one thousand published articles referencing its data

MBF Bioscience unveils whole mouse brain automatic region delineation and cell mapping with the Allen Mouse Brain Reference Atlas

An experimental coronal mouse brain section automatically aligned to the Allen Mouse Brain Reference Atlas

Analyzing cellular populations within specific anatomies in brain images requires expertise in both neuroanatomy and cellular identification. This typically involves a scientist comparing experimental images with a reference atlas and manually delineating anatomical regions and marking cell populations within. NeuroInfo®, a revolutionary new technology from MBF Bioscience, enables researchers to automatically identify and delineate mouse brain regions based on the publicly available Allen Mouse Brain Reference Atlas.

“NeuroInfo has the potential to greatly improve our understanding of how mental disorders influence neuronal cell populations,” says Nathan O’Connor Ph.D., product manager at MBF Bioscience. “Because it makes identifying brain regions substantially faster and more accurate, researchers will be able to explore many more brain regions.”

“The Allen Mouse Brain Reference Atlas is a valuable tool to assist scientists in their research. We’re thrilled that MBF has chosen to integrate this resource into NeuroInfo,” stated Amy Bernard, Ph.D., Product Architect at the Allen Institute for Brain Science.

“Using this remarkable technology, neuroscientists will obtain more repeatable, objective analyses that have been possible to date. Thanks to the integration with the Allen Mouse Brain Reference Atlas, these analyses will be more standardized so that they can be compared across experiments and laboratories,” says Jack Glaser, President.

NeuroInfo can be used with MBF Bioscience’s slide scanning software and virtually all commercial whole slide scanners. The data from NeuroInfo seamlessly integrates with MBF Bioscience’s products including Neurolucida, Stereo Investigator, Biolucida, and BrainMaker.

The tools in NeuroInfo allow researchers to automatically delineate anatomies in the experimental specimens, and detect cells within these anatomies. NeuroInfo yields data that can be invaluable to better understand the organization and composition of the nervous system, and to further knowledge in neurogenomics, transcriptomics, proteomics, and connectomics.

The National Institute of Mental Health provides funding to support the development of NeuroInfo.

Researchers cited MBF Bioscience systems in 30 papers between 09/01/2017 and 09/22/2017

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Bebber, M. R. (2017). Tempered strength: A controlled experiment assessing opportunity costs of adding temper to clay. Journal of Archaeological Science, 86, 1-13. doi: http://dx.doi.org/10.1016/j.jas.2017.08.002.

de Ávila, C., Chometton, S., Lenglos, C., Calvez, J., Gundlach, A. L., & Timofeeva, E. (2017). Differential effects of relaxin-3 and a selective relaxin-3 receptor agonist on food and water intake and hypothalamic neuronal activity in rats. Behavioural Brain Research. doi: http://dx.doi.org/10.1016/j.bbr.2017.08.044.

El-Feky, G. S., El-Banna, S. T., El-Bahy, G. S., Abdelrazek, E. M., & Kamal, M. (2017). Alginate coated chitosan nanogel for the controlled topical delivery of Silver sulfadiazine. Carbohydrate Polymers. doi: http://dx.doi.org/10.1016/j.carbpol.2017.08.104.

Chikama, K., Yamada, H., Tsukamoto, T., Kajitani, K., Nakabeppu, Y., & Uchimura, N. (2017). Chronic atypical antipsychotics, but not haloperidol, increase neurogenesis in the hippocampus of adult mouse. Brain Research, 1676(Supplement C), 77-82. doi: https://doi.org/10.1016/j.brainres.2017.09.006.

Ghuman, H., Gerwig, M., Nicholls, F. J., Liu, J. R., Donnelly, J., Badylak, S. F., & Modo, M. (2017). Long-term retention of ECM hydrogel after implantation into a sub-acute stroke cavity reduces lesion volume. Acta Biomaterialia. doi: https://doi.org/10.1016/j.actbio.2017.09.011.

Hawlitschka, A., Holzmann, C., Witt, S., Spiewok, J., Neumann, A.-M., Schmitt, O., . . . Antipova, V. (2017). Intrastriatally injected botulinum neurotoxin-A differently effects cholinergic and dopaminergic fibers in C57BL/6 mice. Brain Research, 1676(Supplement C), 46-56. doi: https://doi.org/10.1016/j.brainres.2017.09.016.

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Researchers cited MBF Bioscience systems in 27 papers between 08/18/2017 and 09/01/2017

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Balu, D. T., Presti, K. T., Huang, C. C. Y., Muszynski, K., Radzishevsky, I., Wolosker, H., . . . Coyle, J. T. (2017). Serine Racemase and D-serine in the Amygdala are Dynamically Involved in Fear Learning. Biological Psychiatry. doi: 10.1016/j.biopsych.2017.08.012.

Boulanger, J. J., & Messier, C. (2017). Oligodendrocyte progenitor cells are paired with GABA neurons in the mouse dorsal cortex: Unbiased stereological analysis. Neuroscience. doi: http://dx.doi.org/10.1016/j.neuroscience.2017.08.018.

Farrand, A. Q., Helke, K. L., Gregory, R. A., Gooz, M., Hinson, V. K., & Boger, H. A. (2017). Vagus nerve stimulation improves locomotion and neuronal populations in a model of Parkinson’s disease. Brain Stimulation. doi: https://doi.org/10.1016/j.brs.2017.08.008.

Figueiredo, T. H., Harbert, C. L., Pidoplichko, V., Almeida-Suhett, C. P., Pan, H., Rossetti, K., . . . Marini, A. M. (2017). Alpha-Linolenic Acid Treatment Reduces the Contusion and Prevents the Development of Anxiety-Like Behavior Induced by a Mild Traumatic Brain Injury in Rats.  Molecular Neurobiology. doi: 10.1007/s12035-017-0732-y.

Guan, J., Yang, B., Fan, Y., & Zhang, J. (2017). GPER Agonist G1 Attenuates Neuroinflammation and Dopaminergic Neurodegeneration in Parkinson Disease. Neuroimmunomodulation, 0(0), 60-66.

Loris, Z. B., Hynton, J. R., Pieper, A. A., & Dietrich, W. D. (2017). Beneficial Effects of Delayed P7C3-A20 Treatment After Transient MCAO in Rats. Translational Stroke Research. doi: 10.1007/s12975-017-0565-z.

Continue reading “Researchers cited MBF Bioscience systems in 27 papers between 08/18/2017 and 09/01/2017” »

Researchers cited MBF Bioscience systems in 32 papers between 08/11/2017 and 08/18/2017

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Bazzigaluppi, P., Beckett, T. L., Koletar, M. M., Lai, A. Y., Joo, I. L., Brown, M. E., . . . Stefanovic, B. (2017). Early stage attenuation of phase amplitude coupling in the hippocampus and medial prefrontal cortex in a transgenic rat model of AD. Journal of Neurochemistry, n/a-n/a. doi: 10.1111/jnc.14136.

Bull, C., Cooper, C., Lindahl, V., Fitting, S., Persson, A. I., Grandér, R., . . . Blomgren, K. (2017). Exercise in Adulthood after Irradiation of the Juvenile Brain Ameliorates Long-Term Depletion of Oligodendroglial Cells. Radiation Research, 0(0), null. doi: 10.1667/rr14737.1.

Edler, M. K., Sherwood, C. C., Meindl, R. S., Hopkins, W. D., Ely, J. J., Erwin, J. M., . . . Raghanti, M. A. (2017). Aged chimpanzees exhibit pathologic hallmarks of Alzheimer’s disease. Neurobiology of Aging. doi: http://dx.doi.org/10.1016/j.neurobiolaging.2017.07.006.

Fernandez, G. M., & Savage, L. M. (2017). Adolescent binge ethanol exposure alters specific forebrain cholinergic cell populations and leads to selective functional deficits in the prefrontal cortex. Neuroscience. doi: https://doi.org/10.1016/j.neuroscience.2017.08.013.

Hong, J., Wang, L., Zhang, T., Zhang, B., & Chen, L. (2017). Sigma-1 receptor knockout increases α-synuclein aggregation and phosphorylation with loss of dopaminergic neurons in substantia nigra. Neurobiology of Aging. doi: https://doi.org/10.1016/j.neurobiolaging.2017.08.007.

Li, W.-Y., Wang, Y., Zhai, F.-G., Sun, P., Cheng, Y.-X., Deng, L.-X., & Wang, Z.-Y. (2017). AAV-KLF7 Promotes Descending Propriospinal Neuron Axonal Plasticity after Spinal Cord Injury. Neural Plasticity, 2017.

Continue reading “Researchers cited MBF Bioscience systems in 32 papers between 08/11/2017 and 08/18/2017” »

Researchers cited MBF Bioscience systems in 12 papers during the week of 07/10/2017

Stereo Investigator:

Abdurakhmanova, S., Chary, K., Kettunen, M., Sierra, A., & Panula, P. (2017). Behavioral and stereological characterization of Hdc KO mice: relation to Tourette syndrome. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.24279. http://dx.doi.org/10.1002/cne.24279

Filice, F., Celio, M. R., Babalian, A., Blum, W., & Szabolcsi, V. (2017). Parvalbumin-expressing ependymal cells in rostral lateral ventricle wall adhesions contribute to aging-related ventricle stenosis in mice. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.24276. http://dx.doi.org/10.1002/cne.24276

Han, S.-W., Kim, Y.-C., & Narayanan, N. S. (2017). Projection targets of medial frontal D1DR-expressing neurons. Neuroscience Letters. doi: http://dx.doi.org/10.1016/j.neulet.2017.06.057http://www.sciencedirect.com/science/article/pii/S0304394017305487

Lee, J. Q., Sutherland, R. J., & McDonald, R. J. (2017). Hippocampal damage causes retrograde but not anterograde memory loss for context fear discrimination in rats. Hippocampus, n/a-n/a. doi: 10.1002/hipo.22759. http://dx.doi.org/10.1002/hipo.22759

Ma, E. L., Smith, A. D., Desai, N., Cheung, L., Hanscom, M., Stoica, B. A., . . . Faden, A. I. (2017). Bidirectional brain-gut interactions and chronic pathological changes after traumatic brain injury in mice. Brain, Behavior, and Immunity. doi: http://dx.doi.org/10.1016/j.bbi.2017.06.018http://www.sciencedirect.com/science/article/pii/S0889159117302076

Mahar, I., Labonte, B., Yogendran, S., Isingrini, E., Perret, L., Davoli, M. A., . . . Mechawar, N. (2017). Disrupted hippocampal neuregulin-1/ErbB3 signaling and dentate gyrus granule cell alterations in suicide. [Original Article]. Transl Psychiatry, 7, e1161. doi: 10.1038/tp.2017.132. http://dx.doi.org/10.1038/tp.2017.132

Shyng, C., Nelvagal, H. R., Dearborn, J. T., Tyynelä, J., Schmidt, R. E., Sands, M. S., & Cooper, J. D. (2017). Synergistic effects of treating the spinal cord and brain in CLN1 disease. Proceedings of the National Academy of Sciences. doi: 10.1073/pnas.1701832114. http://www.pnas.org/content/early/2017/06/27/1701832114.abstract

Venezia, S., Refolo, V., Polissidis, A., Stefanis, L., Wenning, G. K., & Stefanova, N. (2017). Toll-like receptor 4 stimulation with monophosphoryl lipid A ameliorates motor deficits and nigral neurodegeneration triggered by extraneuronal α-synucleinopathy. [journal article]. Molecular Neurodegeneration, 12(1), 52. doi: 10.1186/s13024-017-0195-7. http://dx.doi.org/10.1186/s13024-017-0195-7

Neurolucida:

Morecraft, R. J., Binneboese, A., Stilwell-Morecraft, K. S., & Ge, J. (2017). Localization of Orofacial Representation in the Corona Radiata, Internal Capsule and Cerebral Peduncle in Macaca mulatta. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.24275. http://dx.doi.org/10.1002/cne.24275

Santello, M., Bisco, A., Nevian, N. E., Lacivita, E., Leopoldo, M., & Nevian, T. (2017). The brain-penetrant 5-HT7 receptor agonist LP-211 reduces the sensory and affective components of neuropathic pain. Neurobiology of Disease. doi: http://dx.doi.org/10.1016/j.nbd.2017.07.005http://www.sciencedirect.com/science/article/pii/S0969996117301584

Scott, B. H., Saleem, K. S., Kikuchi, Y., Fukushima, M., Mishkin, M., & Saunders, R. C. (2017). Thalamic connections of the core auditory cortex and rostral supratemporal plane in the macaque monkey. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.24283. http://dx.doi.org/10.1002/cne.24283

Biolucida:

Sakano, H., Zorio, D. A. R., Wang, X., Ting, Y. S., Noble, W. S., MacCoss, M. J., . . . Wang, Y. (2017). Proteomic analyses of nucleus laminaris identified candidate targets of the fragile X mental retardation protein. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.24281. http://dx.doi.org/10.1002/cne.24281

Researchers cited MBF systems in 29 papers between 6/30/2017 to 7/14/2017

Stereo Investigator:journal images sm

Abdurakhmanova, S., Chary, K., Kettunen, M., Sierra, A., & Panula, P. (2017). Behavioral and stereological characterization of Hdc KO mice: relation to Tourette syndrome. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.24279.

Arathoon, L. R., Gleave, J. A., Trinh, D., Lizal, K. E., Giguère, N., Barber, J. H. M., . . . Nash, J. E. (2017). Sirtuin 3 rescues neurons through the stabilisation of mitochondrial biogenetics in the virally-expressing mutant α-synuclein rat model of parkinsonism. Neurobiology of Disease. doi: https://doi.org/10.1016/j.nbd.2017.06.009.

Chen, L., Wang, X., Lin, Z.-X., Dai, J.-G., Huang, Y.-F., & Zhao, Y.-N. (2017). Preventive Effects of Ginseng Total Saponins on Chronic Corticosterone-Induced Impairment in Astrocyte Structural Plasticity and Hippocampal Atrophy. Phytotherapy Research, n/a-n/a. doi: 10.1002/ptr.5859.

Collette, J. C., Choubey, L., & Smith, K. M. (2017). ­Glial and stem cell expression of murine Fibroblast Growth Factor Receptor 1 in the embryonic and perinatal nervous system. PeerJ, 5, e3519. doi: 10.7717/peerj.3519.

Filice, F., Celio, M. R., Babalian, A., Blum, W., & Szabolcsi, V. (2017). Parvalbumin-expressing ependymal cells in rostral lateral ventricle wall adhesions contribute to aging-related ventricle stenosis in mice. Journal of Comparative Neurology, n/a-n/a. doi: 10.1002/cne.24276.

Finkelstein, D. I., Billings, J. L., Adlard, P. A., Ayton, S., Sedjahtera, A., Masters, C. L., . . . Cherny, R. A. (2017). The novel compound PBT434 prevents iron mediated neurodegeneration and alpha-synuclein toxicity in multiple models of Parkinson’s disease. Acta Neuropathologica Communications, 5(1), 53. doi: 10.1186/s40478-017-0456-2.

Han, S.-W., Kim, Y.-C., & Narayanan, N. S. (2017). Projection targets of medial frontal D1DR-expressing neurons. Neuroscience Letters. doi: http://dx.doi.org/10.1016/j.neulet.2017.06.057.

Lee, J. Q., Sutherland, R. J., & McDonald, R. J. (2017). Hippocampal damage causes retrograde but not anterograde memory loss for context fear discrimination in rats. Hippocampus, n/a-n/a. doi: 10.1002/hipo.22759.

Continue reading “Researchers cited MBF systems in 29 papers between 6/30/2017 to 7/14/2017” »

Researchers cited MBF systems in 8 papers during the week of 06/19/2017

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Kaur, C., Pal, I., Saini, S., Jacob, T. G., Nag, T. C., Thakar, A., . . . Roy, T. S. (2017). Comparison of unbiased stereological estimation of total number of cresyl violet stained neurons and parvalbumin positive neurons in the adult human spiral ganglion. Journal of Chemical Neuroanatomy. doi: https://doi.org/10.1016/j.jchemneu.2017.06.004.

Mani, B. K., Osborne-Lawrence, S., Mequinion, M., Lawrence, S., Gautron, L., Andrews, Z. B., & Zigman, J. M. (2017). The role of ghrelin-responsive mediobasal hypothalamic neurons in mediating feeding responses to fasting. Molecular Metabolism. doi: 10.1016/j.molmet.2017.06.011. http://dx.doi.org/10.1016/j.molmet.2017.06.011

Martinez, E. M., Young, A. L., Patankar, Y. R., Berwin, B. L., Wang, L., von Herrmann, K. M., . . . Havrda, M. C. (2017). Nlrp3 is required for inflammatory changes and nigral cell loss resulting from chronic intragastric rotenone exposure in mice. Toxicological Sciences. https://academic.oup.com/toxsci/article-abstract/doi/10.1093/toxsci/kfx1…

Po, K. K.-t., Leung, J. W.-h., Chan, J. N.-m., Fung, T. K.-h., Sánchez-Vidaña, D. I., Sin, E. L.-l., . . . Siu, A. M.-h. (2017). Protective effect of Lycium Barbarum polysaccharides on dextromethorphan-induced mood impairment and neurogenesis suppression. Brain Research Bulletin, 134, 10-17. doi: https://doi.org/10.1016/j.brainresbull.2017.06.014.  Continue reading “Researchers cited MBF systems in 8 papers during the week of 06/19/2017” »