Huron Digital Pathology and MBF Bioscience Partner to Enable Large-scale, Repeatable Whole Slide Imaging Workflows for Life Science Research

MBF Bioscience now offers customized models of Huron Digital Pathology’s TissueScope™, a line of whole slide scanners, and supports TissueScope images across its range of analysis software.

October 23, 2018 – Huron Digital Pathology and MBF Bioscience are proud to announce their partnership to offer customized models of Huron’s TissueScope whole slide scanners integrated with MBF’s Stereo Investigator® – Whole Slide Edition, NeuroInfo®, Biolucida®, and BrainMaker® software. The partnership gives researchers new tools to visualize and analyze tissue specimens throughout entire organs, large and small, at high-resolution.

“Combining our analysis software with Huron’s whole slide scanners means that researchers can get the most advanced systems for large-scale, repeatable whole slide imaging workflows,” says Jack Glaser, President of MBF Bioscience. “We are pleased to partner with Huron Digital Pathology to provide Huron/MBF whole slide research systems. As the recognized leader in the fields of stereology, brain mapping, and neuron tracing, we are proud to offer systems with such a distinguished company as Huron. This partnership will now allow researchers to effectively work with microscopic specimens that range in size from mice brains to human brains. It is invaluable for researchers working with large brain specimens, especially those investigating the microscopic intricacies of the human brain.”

“By partnering with MBF Bioscience, our goal is to help accelerate life science research,” says Patrick Myles, CEO of Huron Digital Pathology. “Being able to scan any size tissue and then easily manage, visualize, and quantify the data opens up amazing new possibilities for scientific research and exploration.”

The partnership enables Stereo Investigator, NeuroInfo, Biolucida, and BrainMaker software to efficiently provide quantitative analysis workflows for large sets of slides from both individual tissue sections and series of tissue sections. Stereo Investigator – Whole Slide Edition offers analyses for counting and measuring morphological aspects relevant to disease state characterization. BrainMaker and NeuroInfo offer full-resolution section alignment and brain mapping. Biolucida offers slide management and slide access for viewing and analysis at unprecedented speeds from any web-enabled device. The customized versions of TissueScope scanners are available for purchase from MBF Bioscience.

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MBF Bioscience’s New Software Vesselucida 360 Reconstructs Microvascular Networks in 3D

Williston, VT – September 5, 2018 – Researchers studying microvascular networks and vessels have a groundbreaking new software application to facilitate their work. Developed by MBF Bioscience, Vesselucida® 360 automatically reconstructs and analyzes microvascular networks in 3D.

Specifically designed to recognize the intricacies of the vascular system, Vesselucida features sophisticated algorithms that quickly and accurately create 3D reconstructions of images and tissue specimens. Built-in analyses provide data on segments and node counts, frequency of anastomoses, as well as metrics on vessel surface and volume.

Automatic reconstruction of vascular structure labeled with tomato lectin
Image courtesy Dr. Stan Watson, University of Michigan, USA

Vesselucida 360 also features a full suite of tools, which lets researchers manually trace and edit 3D reconstructions to fine-tune particularly complex image data. Companion analysis software, Vesselucida Explorer performs sophisticated data analysis for scientists seeking answers to their most challenging research questions.

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MBF Bioscience Launches Stereo Investigator Whole Slide Edition for Quantitative Analysis of Whole Slide Image Data

Williston, VT – June 29, 2018 – MBF Bioscience is pleased to announce the launch of the Whole Slide Edition of Stereo Investigator. This is a new version of our renown Stereo Investigator software, designed especially for conducting stereology on images from slide scanners.

Featuring a streamlined, user-friendly interface, this new product includes a variety of probes for quantifying number, length, volume, and surface area of cells, structures, and regions of biological tissue. The software works with all 2D microscope images, and is an especially attractive solution for researchers who work mostly, or exclusively, with slide scanners.

The main benefits of Stereo Investigator – Whole Slide Edition include:
· Accurate, unbiased quantitative analysis of images from slide scanners
· Designed workflows and user-interface specifically for analyzing whole slide images
· Compatible with all popular slide scanning file formats
· Enhanced user interface that is easy to use for 2D stereology probes
· Integrates with our Biolucida image management system
· Affordable
· Includes MBF technical and scientific support
· Free trial versions are available

“We’re very excited about the opportunity this gives to many of our customers who want to use stereology to perform quantitative analysis of their whole slide image data. Stereo Investigator – Whole Slide Edition provides a powerful, lower-cost version of Stereo Investigator with a user interface designed specifically for 2D image data,” says MBF Bioscience Director of Sales & Marketing Mark Barton.

For over a decade, Stereo Investigator has been considered the gold standard for carrying out stereological studies on biological tissue, and is cited in peer reviewed publications ten times more than any other stereology system. With the release of Stereo Investigator – Whole Slide Edition, MBF Bioscience continues its dedication to further assisting the research of our valued customers.

For more information about Stereo Investigator Whole Slide Edition and to request a quote, visit http://www.mbfbioscience.com/stereo-investigator-whole-slide-edition

Researchers cited MBF Bioscience systems in 27 papers between 3/23/2018 and 4/6/2018

Stereo Investigator: 
Crupi, R., Impellizzeri, D., Cordaro, M., Siracusa, R., Casili, G., Evangelista, M., & Cuzzocrea, S. (2018). N-palmitoylethanolamide Prevents Parkinsonian Phenotypes in Aged Mice.  Molecular Neurobiology. doi: 10.1007/s12035-018-0959-2.

Dingle, A. M., Yap, K. K., Gerrand, Y.-W., Taylor, C. J., Keramidaris, E., Lokmic, Z., . . . Mitchell, G. M. (2018). Characterization of isolated liver sinusoidal endothelial cells for liver bioengineering. Angiogenesis. doi: 10.1007/s10456-018-9610-0.

Duthie, M. S., Pena, M. T., Ebenezer, G. J., Gillis, T. P., Sharma, R., Cunningham, K., . . . Reed, S. G. (2018). LepVax, a defined subunit vaccine that provides effective pre-exposure and post-exposure prophylaxis of M. leprae infection. npj Vaccines, 3(1), 12. doi: 10.1038/s41541-018-0050-z.

Dutta, R. R., Taffe, M. A., & Mandyam, C. D. (2018). Chronic administration of amphetamines disturbs development of neural progenitor cells in young adult nonhuman primates. Progress in Neuro-Psychopharmacology and Biological Psychiatry. doi: https://doi.org/10.1016/j.pnpbp.2018.03.023.

Hormigo, S., López, D. E., Cardoso, A., Zapata, G., Sepúlveda, J., & Castellano, O. (2018). Direct and indirect nigrofugal projections to the nucleus reticularis pontis caudalis mediate in the motor execution of the acoustic startle reflex. Brain Structure and Function. doi: 10.1007/s00429-018-1654-9.

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Researchers cited MBF Bioscience systems in 13 papers between 3/16/2018 and 3/23/2018

Stereo Investigator:
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Cisbani, G., Le Behot, A., Plante, M.-M., Préfontaine, P., Lecordier, M., & Rivest, S. (2018). Role of the chemokine receptors CCR2 and CX3CR1 in an experimental model of thrombotic stroke. Brain, Behavior, and Immunity. doi: https://doi.org/10.1016/j.bbi.2018.03.008.

Du, R.-H., Sun, H.-B., Hu, Z.-L., Lu, M., Ding, J.-H., & Hu, G. (2018). Kir6.1/K-ATP channel modulates microglia phenotypes: implication in Parkinson’s disease. Cell death & disease, 9(3), 404. doi: 10.1038/s41419-018-0437-9.

McGowan, S. E., & McCoy, D. M. (2018). Neuropilin-1and platelet-derived growth factor receptors cooperatively regulate intermediate filaments and mesenchymal cell migration during alveolar septation. American Journal of Physiology-Lung Cellular and Molecular Physiology.

Nagahara, A. H., Wilson, B. R., Ivasyk, I., Kovacs, I., Rawalji, S., Bringas, J. R., . . . Bankiewicz, K. S. (2018). MR-guided delivery of AAV2-BDNF into the entorhinal cortex of non-human primates. Gene Therapy, 1.

Neurolucida:

Brudvig, J. J., Cain, J. T., Schmidt-Grimminger, G. G., Stumpo, D. J., Roux, K. J., Blackshear, P. J., & Weimer, J. M. (2018). MARCKS Is Necessary for Netrin-DCC Signaling and Corpus Callosum Formation.  Molecular Neurobiology. doi: 10.1007/s12035-018-0990-3.

Carr, H., Alexander, T. C., Groves, T., Kiffer, F., Wang, J., Price, E., . . . Allen, A. R. (2018). Early effects of 16O radiation on Neuronal Morphology and Cognition in a Murine Model. Life Sciences in Space Research. doi: https://doi.org/10.1016/j.lssr.2018.03.001Continue reading “Researchers cited MBF Bioscience systems in 13 papers between 3/16/2018 and 3/23/2018” »

Researchers cited MBF Bioscience systems in 11 papers between 3/9/2018 and 3/16/2018

Stereo Investigator:
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Deroche-Gamonet, V., Revest, J.-M., Fiancette, J.-F., Balado, E., Koehl, M., Grosjean, N., . . . Piazza, P.-V. (2018). Depleting adult dentate gyrus neurogenesis increases cocaine-seeking behavior. Molecular Psychiatry. doi: 10.1038/s41380-018-0038-0.

Mendez-Gomez, H. R., Singh, J., Meyers, C., Chen, W., Gorbatyuk, O. S., & Muzyczka, N. (2018). The Lipase Activity of Phospholipase D2 is Responsible for Nigral Neurodegeneration in a Rat Model of Parkinson’s Disease. Neuroscience. doi: https://doi.org/10.1016/j.neuroscience.2018.02.047.

Wang, Y., Wang, Y., Liu, J., & Wang, X. (2018). Electroacupuncture Alleviates Motor Symptoms and Up-Regulates Vesicular Glutamatergic Transporter 1 Expression in the Subthalamic Nucleus in a Unilateral 6-Hydroxydopamine-Lesioned Hemi-Parkinsonian Rat Model.  Neuroscience bulletin. doi: 10.1007/s12264-018-0213-y.

Neurolucida:

Borreca, A., Latina, V., Corsetti, V., Middei, S., Piccinin, S., Della Valle, F., . . . Amadoro, G. (2018). AD-Related N-Terminal Truncated Tau Is Sufficient to Recapitulate In Vivo the Early Perturbations of Human Neuropathology: Implications for Immunotherapy. Molecular Neurobiology. doi: 10.1007/s12035-018-0974-3.

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Researchers cited MBF Bioscience systems in 28 papers between 3/2/2018 and 3/9/2018

Stereo Investigator:
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Akca, G., Eren, H., Tumkaya, L., Mercantepe, T., Horsanali, M. O., Deveci, E., . . . Yilmaz, A. (2018). The protective effect of astaxanthin against cisplatin-induced nephrotoxicity in rats. Biomedicine and Pharmacotherapy, 100, 575-582. doi: https://doi.org/10.1016/j.biopha.2018.02.042.

Aytan, N., Choi, J.-K., Carreras, I., Crabtree, L., Nguyen, B., Lehar, M., . . . Dedeoglu, A. Protective effects of 7,8-dihydroxyflavone on neuropathological and neurochemical changes in a mouse model of Alzheimer’s disease. European Journal of Pharmacology. doi: https://doi.org/10.1016/j.ejphar.2018.02.045.

Chu, X., Zhou, S., Sun, R., Wang, L., Xing, C., Liang, R., & Kong, Q. (2018). Chrysophanol Relieves Cognition Deficits and Neuronal Loss Through Inhibition of Inflammation in Diabetic Mice. Neurochemical Research. doi: 10.1007/s11064-018-2503-1. https://doi.org/10.1007/s11064-018-2503-1

Domínguez-Álvaro, M., Montero-Crespo, M., Blazquez-Llorca, L., Insausti, R., DeFelipe, J., & Alonso-Nanclares, L. (2018). Three-dimensional analysis of synapses in the transentorhinal cortex of Alzheimer’s disease patients. Acta Neuropathologica Communications, 6(1), 20. doi: 10.1186/s40478-018-0520-6.

El Massri, N., Weinrich, T. W., Kam, J. H., Jeffery, G., & Mitrofanis, J. (2018). Photobiomodulation reduces gliosis in the basal ganglia of aged mice. Neurobiology of Aging. doi: https://doi.org/10.1016/j.neurobiolaging.2018.02.019.

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American Association of Anatomists Launches Virtual Microscopy Database powered by Biolucida

Free resource for educators and researchers features thousands of downloadable histology slides

Educators and researchers around the world now have free access to a database of whole slide images (also known as virtual slides) for histology and pathology. Featuring thousands of virtual slides contributed by 15 universities, The Virtual Microscopy Database, VMD, (http://www.virtualmicroscopydatabase.org/) is an online resource that allows educators to view and download virtual images and share their own.

Powered by MBF Bioscience‘s Biolucida® for Medical Education solution, VMD gives educators an overview of individual slides and allows examination of various parts of the image at magnifications up to 40x. The users can take a screenshot or download the file at any time.

Funded by an Innovations Program Grant awarded by the American Association of Anatomists (AAA), the resource was developed by researchers from the University of Colorado, Drexel University College of Medicine, and the University of Michigan with corporate support from MBF Bioscience. With thousands of freely accessible virtual microscopy images, the VMD helps meet a growing need for better access to histology slides among educators and non-profit research organizations. The AAA foresees the images being used in a variety of educational ways such as for lectures, exams, and for creating supplementary course material as well as for non-profit research initiatives.

Collection of Virtual Slides in the Biolucida Viewer

“The greatest strength of the VMD is the availability of a large number of high quality virtual microscopy images to its users. The diversity and multiple examples of histological variations available in the VMD collections will enable histology and pathology educators to elevate the quality of their teaching by exposing their students to a broader variety of images and by experimenting with new pedagogical techniques in their classrooms.” (Lisa Lee, Ph.D., University of Colorado)

“We are proud to be part of the AAA’s efforts to improve the access of histology and pathology digital slides for medical educators and students by providing the underlying technology for this important resource. Any of the virtual slides in this new resource can be downloaded and used on an organization’s Biolucida on-premise or cloud-based server,” says Jack Glaser, president of MBF Bioscience.

Individuals affiliated with educational or research institutions may register to access the database. Once approved, users can browse files, or search for specific types of tissue. Currently, the VMD site includes over 2,600 virtual microscopy files, but as new users join the VMD file sharing community that number will grow as will the diversity of tissue and species type.

About AAA:

The American Association of Anatomists was founded by Joseph Leidy in Washington, D.C. in 1888 for the “advancement of anatomical science.” Today, via research, education, and professional development activities, AAA serves as the professional home for an international community of biomedical researchers and educators focusing on the structural foundation of health and disease.

About MBF Bioscience:

MBF Bioscience produces advanced microscopy imaging and analysis systems for biomedical research and education. The award-winning company was co-founded in 1988 by Edmund and Jack Glaser.

www.mbfbioscience.com

Contact:

Nathan O’Connor, Ph.D.

Product Manager/Technical Sales

nate.oconnor@mbfbioscience.com

1-802-288-9290

Researchers cited MBF Bioscience systems in 15 papers between 12/8/2017 and 12/15/2017

Stereo Investigator:
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Garcia-Miralles, M., Geva, M., Tan, J. Y., Yusof, N. A. B. M., Cha, Y., Kusko, R., . . . Pouladi, M. A. (2017). Early pridopidine treatment improves behavioral and transcriptional deficits in YAC128 Huntington disease mice. JCI Insight, 2(23). doi: 10.1172/jci.insight.95665.

Gomez-Smith, M., Janik, R., Lake, E. M., Thomason, L. A. M., Adams, C., Jeffers, M. S., . . . Corbett, D. (2017). Reduced Cerebrovascular Reactivity and Increased Resting Cerebral Perfusion in Rats Exposed to a Cafeteria Diet. Neuroscience. doi: https://doi.org/10.1016/j.neuroscience.2017.11.054.

Hawkins, R. F. W., Patenaude, A., Dumas, A., Jain, R., Tesfagiorgis, Y., Kerfoot, S., . . . Vallières, L. (2017). ICAM1+ neutrophils promote chronic inflammation via ASPRV1 in B cell–dependent autoimmune encephalomyelitis. JCI Insight, 2(23). doi: 10.1172/jci.insight.96882.

Joseph, M., Anglada-Huguet, M., Paesler, K., Mandelkow, E., & Mandelkow, E.-M. (2017). Anti-aggregant tau mutant promotes neurogenesis. Molecular Neurodegeneration, 12(1), 88. doi: 10.1186/s13024-017-0230-8.

Kelm-Nelson, C. A., Brauer, A. F. L., Barth, K. J., Lake, J. M., Sinnen, M. L. K., Stehula, F. J., . . . Ciucci, M. R. (2018). Characterization of early-onset motor deficits in the Pink1−/− mouse model of Parkinson disease. Brain Research, 1680, 1-12. doi: https://doi.org/10.1016/j.brainres.2017.12.002.

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NeuroMorpho.Org Releases Nearly 10,000 New Neuron Reconstructions and Neurolucida leads the way

Image Courtesy: Bob Jacobs, Ph.D. , Colorado College

With the release of its new version on November 28, NeuroMorpho.org adds 9,987 new images to its archive, bringing its impressive collection of digitally reconstructed neurons to 80,012.

Scientists used MBF Bioscience’s software, Neurolucida and Neurolucida 360, to reconstruct the majority of these cells. In fact, 64 times more neurons were reconstructed with MBF Bioscience software than those imaged by our closest commercial competitor – that’s 42,121 reconstructions compared to 656. This metric demonstrates that Neurolucida and Neurolucida 360 are truly the gold standards for neuron reconstruction.

Featuring contributions from hundreds of laboratories from around the globe, NeuroMorpho.Org is the world’s leading database of publicly accessible 3D neuronal reconstructions and associated metadata. From the dragonfly to the humpback whale, researchers have access to accurate and verified data from an array of different organisms. Arranged by animal species, brain region, cell type, or contributing laboratory, each file contains specific details about the cell’s morphology such as age, developmental stage, soma volume, and number of branches – all of which are searchable.

Recently, NeuroMorpho.Org hit the 8 million download mark, with researchers in 166 different countries accessing this valuable resource, and more than one thousand published articles referencing its data